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Article

Cognitive and neural signatures of the APOE E4 allele in mid-aged adults.

Neurobiology of aging - 1 Jul 2014

Evans Simon, Dowell Nicholas G, Tabet Naji, Tofts Paul S, King Sarah L, Rusted Jennifer M

Abstract excerpt

The apolipoprotein E (APOE) e4 allele is strongly associated with increased risk of cognitive impairments in older adulthood. There is also a possible link to enhanced cognitive performance in younger adults, and the APOE e4 allele may constitute an example of antagonistic pleiotropy. The aim of this work was to investigate the cognitive and neural (functional) effects of the APOE e4 allele during mid-age (45-55...

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Identifiers

PMID: 24582638
DOI: 10.1016/j.neurobiolaging.2014.01.145
PMCID: PMC4001126

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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