Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2009

Filippini Nicola, MacIntosh Bradley J, Hough Morgan G, Goodwin Guy M, Frisoni Giovanni B, Smith Stephen M, Matthews Paul M, Beckmann Christian F, Mackay Clare E

Abstract excerpt

The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects. We investigated structural and functional effects of the APOE polymorphism in 18 young healthy APOE epsilon4-carriers and 18 matched noncarriers (age range: 20-35 years). Brain activity was studied both at rest and during an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced MRI Techniques and Applications
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Functional Brain Connectivity Studies

Share to APOE gene

Share to Magnetic Resonance Imaging

Share to Memory

Source

Open in PubMed Open full text

Identifiers

PMID: 19357304
DOI: 10.1073/pnas.0811879106
PMCID: PMC2678478

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele.PMID 19357304Read ↗

Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.Semantic proximity Read ↗

APOE related alterations in cerebral activation even at college age.Semantic proximity Read ↗

APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults.Semantic proximity Read ↗

APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging.Semantic proximity Read ↗

Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.Semantic proximity Read ↗

Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers.Semantic proximity Read ↗

Imaging studies and APOE genotype in persons at risk for Alzheimer's disease.Semantic proximity Read ↗

Differential effects of the APOE genotype on brain function across the lifespan.Semantic proximity Read ↗

APOE Polymorphism Affects Brain Default Mode Network in Healthy Young AdultsSemantic proximity Read ↗

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.Semantic proximity Read ↗

Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.Semantic proximity Read ↗

ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer's Disease Support Memory Performance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.