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Article

The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease.

Neurobiology of aging - 1 Mar 2012

Trachtenberg Aaron J, Filippini Nicola, Cheeseman Jane, Duff Eugene P, Neville Matt J, Ebmeier Klaus P, Karpe Fredrik, Mackay Clare E

Abstract excerpt

Possession of the APOE-ε4 allele is the best established genetic risk factor for sporadic Alzheimer's disease (AD), while the ε2 allele may confer protection against the disease. Previous functional magnetic resonance imaging (fMRI) studies have shown an effect of APOE genotype on brain function, typically by comparing only ε4 carriers with noncarriers. Here we included a wide range of genotype groups to...

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Source

Identifiers

PMID: 21232817
DOI: 10.1016/j.neurobiolaging.2010.11.011

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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