Article
Hotspot TERT promoter mutations are rare events in testicular germ cell tumors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2016
Cárcano Flavio Mavignier, Vidal Daniel Onofre, van Helvoort Lengert André, Neto Cristovam Scapulatempo, Queiroz Luisa, Marques Herlander, Baltazar Fátima, da Silva Martinelli Camila Maria, Soares Paula, da Silva Eduardo Caetano Albino, Lopes Luiz Fernando, Reis Rui Manuel
Abstract excerpt
The abnormal activation of telomerase, codified by the telomerase reverse transcriptase (TERT) gene, is related to one of cancer hallmarks. Hotspot somatic mutations in the promoter region of TERT, specifically the c.-124:C>T and c.-146:C>T, were recently identified in a range of human cancers and have been associated with a more aggressive behavior. Testicular germ cell tumors frequently exhibit a good...
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