Article
Understanding TERT Promoter Mutations: A Common Path to Immortality.
Molecular cancer research : MCR - 1 Apr 2016
Bell Robert J A, Rube H Tomas, Xavier-Magalhães Ana, Costa Bruno M, Mancini Andrew, Song Jun S, Costello Joseph F
Abstract excerpt
Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless proliferation driven by oncogenes. The recently discovered, highly recurrent mutations in the promoter of TERT are found in over 50 cancer types, and are the most common mutation in many cancers. Transcriptional activation of TERT, via...
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