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Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer

31 Oct 2021

Abstract excerpt

Aberrant activation of telomerase in human cancer is achieved by various alterations within the TERT promoter, including cancer-specific DNA hypermethylation of the TERT hypermethylated oncological region (THOR). However, the impact of allele-specific DNA methylation within the TERT promoter on gene transcription remains incompletely understood. Using allele-specific next-generation sequencing, we screened a...

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PMID: 34720085
DOI: 10.1172/jci146915

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