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Article

Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs).

European journal of human genetics : EJHG - 1 Jun 2015

Campanella Nathália C, Celestino Ricardo, Pestana Ana, Scapulatempo-Neto Cristovam, de Oliveira Antonio Talvane, Brito Maria José, Gouveia António, Lopes José Manuel, Guimarães Denise Peixoto, Soares Paula, Reis Rui M

Abstract excerpt

Somatic mutations in the promoter region of telomerase reverse transcriptase (TERT) gene, mainly at positions c.-124 and c.-146 bp, are frequent in several human cancers; yet its presence in gastrointestinal stromal tumor (GIST) has not been reported to date. Herein, we searched for the presence and clinicopathological association of TERT promoter mutations in genomic DNA from 130 bona fide GISTs. We found TERT...

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Share to Gastrointestinal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Tumor Research and Treatment

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Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 25248398
DOI: 10.1038/ejhg.2014.195
PMCID: PMC4795049

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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