Article
Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.
Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2020
Esopi David, Graham Mindy Kim, Brosnan-Cashman Jacqueline A, Meyers Jennifer, Vaghasia Ajay, Gupta Anuj, Kumar Balasubramanian, Haffner Michael C, Heaphy Christopher M, De Marzo Angelo M, Meeker Alan K, Nelson William G, Wheelan Sarah J, Yegnasubramanian Srinivasan
Abstract excerpt
BACKGROUND: In cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT. Yet, most cancers show only modest levels of TERT gene expression, even in the context of activating hotspot promoter mutations (C228T and C250T). The role of epigenetic mechanisms, including DNA methylation, in regulating TERT gene expression in cancer cells is as yet not...
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