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Article

Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications

18 Jul 2016

Abstract excerpt

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of linear chromosomes, and attenuates or prevents telomere erosion associated with cell divisions. By lengthening telomeres, telomerase extends cellular life-span or even induces immortalization. Consistent with its functional activity, telomerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27438857
DOI: 10.3390/genes7070038

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