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New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

25 Aug 2020

Abstract excerpt

Abstract The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations in the promoter region (TERTp), i.e. c.1-124 C > T, c.1-146 C > T, confers a proliferative advantage to neoplastic...

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PMID: 32843091
DOI: 10.1186/s40478-020-01022-4

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