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Article

The Solo Play of TERT Promoter Mutations.

Cells - 19 Mar 2020

Hafezi François, Perez Bercoff Danielle

Abstract excerpt

The reactivation of telomerase reverse transcriptase (TERT) protein is the principal mechanism of telomere maintenance in cancer cells. Mutations in the TERT promoter (TERTp) are a common mechanism of TERT reactivation in many solid cancers, particularly those originating from slow-replicating tissues. They are associated with increased TERT levels, telomere stabilization, and cell immortalization and...

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Share to Mutation
Share to Neoplasms
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Telomerase

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Identifiers

PMID: 32204305
DOI: 10.3390/cells9030749
PMCID: PMC7140675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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