Article
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers.
Expert review of molecular diagnostics - 1 Nov 2022
Marchese Paola Valeria, Mollica Veronica, Tassinari Elisa, De Biase Dario, Giunchi Francesca, Marchetti Andrea, Rosellini Matteo, Fiorentino Michelangelo, Massari Francesco
Abstract excerpt
INTRODUCTION: The reactivation of telomerase represents a key moment in the carcinogenesis process. Mutations in the central promoter region of the telomerase reverse transcriptase (TERT) gene cause telomerase reactivation in approximately 90% of solid tumors. In some of these, its prognostic and predictive role in response to treatments has already been demonstrated, in others (such as tumors of the...
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