Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.

doi:10.1016/j.ejca.2015.03.010

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Article

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.

European journal of cancer (Oxford, England : 1990) - 1 May 2015

Huang Dong-Sheng, Wang Zhaohui, He Xu-Jun, Diplas Bill H, Yang Rui, Killela Patrick J, Meng Qun, Ye Zai-Yuan, Wang Wei, Jiang Xiao-Ting, Xu Li, He Xiang-Lei, Zhao Zhong-Sheng, Xu Wen-Juan, Wang Hui-Ju, Ma Ying-Yu, Xia Ying-Jie, Li Li, Zhang Ru-Xuan, Jin Tao, Zhao Zhong-Kuo, Xu Ji, Yu Sheng, Wu Fang, Liang Junbo, Wang Sizhen, Jiao Yuchen, Yan Hai, Tao Hou-Quan

Abstract excerpt

BACKGROUND: Several somatic mutation hotspots were recently identified in the telomerase reverse transcriptase (TERT) promoter region in human cancers. Large scale studies of these mutations in multiple tumour types are limited, in particular in Asian populations. This study aimed to: analyse TERT promoter mutations in multiple tumour types in a large Chinese patient cohort, investigate novel tumour types and...

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Identifiers

PMID: 25843513
DOI: 10.1016/j.ejca.2015.03.010
PMCID: PMC4467782

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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