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Article

Occurrence, functionality and abundance of the TERT promoter mutations.

International journal of cancer - 1 Dec 2021

Rachakonda Sivaramakrishna, Hoheisel Jörg D, Kumar Rajiv

Abstract excerpt

Telomere shortening at chromosomal ends due to the constraints of the DNA replication process acts as a tumor suppressor by restricting the replicative potential in primary cells. Cancers evade that limitation primarily through the reactivation of telomerase via different mechanisms. Mutations within the promoter of the telomerase reverse transcriptase (TERT) gene represent a definite mechanism for the...

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Identifiers

PMID: 34313327
DOI: 10.1002/ijc.33750

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