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Article

Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets.

Nature genetics - 1 Jun 2024

Frei Oleksandr, Hindley Guy, Shadrin Alexey A, van der Meer Dennis, Akdeniz Bayram C, Hagen Espen, Cheng Weiqiu, O'Connell Kevin S, Bahrami Shahram, Parker Nadine, Smeland Olav B, Holland Dominic, de Leeuw Christiaan, Posthuma Danielle, Andreassen Ole A, Dale Anders M

Abstract excerpt

While genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging. Here we developed the GSA-MiXeR analytical tool for gene set analysis (GSA), which fits a model for the heritability of individual genes, accounting for linkage disequilibrium across variants and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38831010
DOI: 10.1038/s41588-024-01771-1

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