Article
nMAGMA: a network-enhanced method for inferring risk genes from GWAS summary statistics and its application to schizophrenia.
Briefings in bioinformatics - 20 Jul 2021
Yang Anyi, Chen Jingqi, Zhao Xing-Ming
Abstract excerpt
MOTIVATION: Annotating genetic variants from summary statistics of genome-wide association studies (GWAS) is crucial for predicting risk genes of various disorders. The multimarker analysis of genomic annotation (MAGMA) is one of the most popular tools for this purpose, where MAGMA aggregates signals of single nucleotide polymorphisms (SNPs) to their nearby genes. In biology, SNPs may also affect genes that are...
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