Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.

doi:10.1186/s13073-017-0497-y

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Article

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.

Genome medicine - 20 Dec 2017

Nguyen Hoang T, Bryois Julien, Kim April, Dobbyn Amanda, Huckins Laura M, Munoz-Manchado Ana B, Ruderfer Douglas M, Genovese Giulio, Fromer Menachem, Xu Xinyi, Pinto Dalila, Linnarsson Sten, Verhage Matthijs, Smit August B, Hjerling-Leffler Jens, Buxbaum Joseph D, Hultman Christina, Sklar Pamela, Purcell Shaun M, Lage Kasper, He Xin, Sullivan Patrick F, Stahl Eli A

Abstract excerpt

BACKGROUND: Integrating rare variation from trio family and case-control studies has successfully implicated specific genes contributing to risk of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASD), intellectual disability (ID), developmental disorders (DDs), and epilepsy (EPI). For schizophrenia (SCZ), however, while sets of genes have been implicated through the study of rare...

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PMID: 29262854
DOI: 10.1186/s13073-017-0497-y
PMCID: PMC5738153

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