Article
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.
The American journal of psychiatry - 1 Feb 2015
Arnedo Javier, Svrakic Dragan M, Del Val Coral, Romero-Zaliz Rocío, Hernández-Cuervo Helena, Fanous Ayman H, Pato Michele T, Pato Carlos N, de Erausquin Gabriel A, Cloninger C Robert, Zwir Igor
Abstract excerpt
OBJECTIVE: The authors sought to demonstrate that schizophrenia is a heterogeneous group of heritable disorders caused by different genotypic networks that cause distinct clinical syndromes. METHOD: In a large genome-wide association study of cases with schizophrenia and controls, the authors first identified sets of interacting single-nucleotide polymorphisms (SNPs) that cluster within particular individuals...
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