Article
Comparative genetic architectures of schizophrenia in East Asian and European populations.
Nature genetics - 1 Dec 2019
Lam Max, Chen Chia-Yen, Li Zhiqiang, Martin Alicia R, Bryois Julien, Ma Xixian, Gaspar Helena, Ikeda Masashi, Benyamin Beben, Brown Brielin C, Liu Ruize, Zhou Wei, Guan Lili, Kamatani Yoichiro, Kim Sung-Wan, Kubo Michiaki, Kusumawardhani Agung A A A, Liu Chih-Min, Ma Hong, Periyasamy Sathish, Takahashi Atsushi, Xu Zhida, Yu Hao, Zhu Feng, Chen Wei J, Faraone Stephen, Glatt Stephen J, He Lin, Hyman Steven E, Hwu Hai-Gwo, McCarroll Steven A, Neale Benjamin M, Sklar Pamela, Wildenauer Dieter B, Yu Xin, Zhang Dai, Mowry Bryan J, Lee Jimmy, Holmans Peter, Xu Shuhua, Sullivan Patrick F, Ripke Stephan, O'Donovan Michael C, Daly Mark J, Qin Shengying, Sham Pak, Iwata Nakao, Hong Kyung S, Schwab Sibylle G, Yue Weihua, Tsuang Ming, Liu Jianjun, Ma Xiancang, Kahn René S, Shi Yongyong, Huang Hailiang
Abstract excerpt
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations...
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