Article

Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder

2026-07-09

Abstract excerpt

Schizophrenia (SCZ) and bipolar disorder (BIP) share substantial common-variant liability but differ in cognitive, comorbidity, and treatment response. Here we decomposed these disorders into schizophrenia-predominant, bipolar-predominant, and shared psychosis dimensions to test whether these components show distinct pleiotropic and biological profiles than the original disorder. Using the largest available SCZ an...

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Literature Corpus work: b87a00b0-93a9-53f6-b773-29baeaace7da
DOI: 10.64898/2026.07.07.26357436

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