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Article

Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals.

Human brain mapping - 1 Feb 2016

Lancaster Thomas M, Ihssen Niklas, Brindley Lisa M, Tansey Katherine E, Mantripragada Kiran, O'Donovan Michael C, Owen Michael J, Linden David E J

Abstract excerpt

A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total of common risk variants weighted by their effect. Previous studies suggest that schizophrenia RPS predict alterations to neural networks that support working memory and verbal fluency. In this study, we apply schizophrenia RPS to fMRI data to...

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Identifiers

PMID: 26510167
DOI: 10.1002/hbm.23044
PMCID: PMC4949629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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