A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans.

doi:10.1016/j.euroneuro.2017.06.005

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Article

A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Sept 2017

Rampino Antonio, Taurisano Paolo, Fanelli Giuseppe, Attrotto Mariateresa, Torretta Silvia, Antonucci Linda Antonella, Miccolis Grazia, Pergola Giulio, Ursini Gianluca, Maddalena Giancarlo, Romano Raffaella, Masellis Rita, Di Carlo Pasquale, Pignataro Patrizia, Blasi Giuseppe, Bertolino Alessandro

Abstract excerpt

Multiple genetic variations impact on risk for schizophrenia. Recent analyses by the Psychiatric Genomics Consortium (PGC2) identified 128 SNPs genome-wide associated with the disorder. Furthermore, attention and working memory deficits are core features of schizophrenia, are heritable and have been associated with variation in glutamatergic neurotransmission. Based on this evidence, in a sample of healthy...

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PMID: 28651857
DOI: 10.1016/j.euroneuro.2017.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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