Article
Prefrontal inefficiency is associated with polygenic risk for schizophrenia.
Schizophrenia bulletin - 1 Nov 2014
Walton Esther, Geisler Daniel, Lee Phil H, Hass Johanna, Turner Jessica A, Liu Jingyu, Sponheim Scott R, White Tonya, Wassink Thomas H, Roessner Veit, Gollub Randy L, Calhoun Vince D, Ehrlich Stefan
Abstract excerpt
Considering the diverse clinical presentation and likely polygenic etiology of schizophrenia, this investigation examined the effect of polygenic risk on a well-established intermediate phenotype for schizophrenia. We hypothesized that a measure of cumulative genetic risk based on additive effects of many genetic susceptibility loci for schizophrenia would predict prefrontal cortical inefficiency during working...
Topics
- Adult
- Case-Control Studies
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Memory, Short-Term
- Middle Aged
- Multifactorial Inheritance
- Phenotype
- Polymorphism, Single Nucleotide