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Article

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity.

Brain : a journal of neurology - 1 Apr 2018

Chen Qiang, Ursini Gianluca, Romer Adrienne L, Knodt Annchen R, Mezeivtch Karleigh, Xiao Ena, Pergola Giulio, Blasi Giuseppe, Straub Richard E, Callicott Joseph H, Berman Karen F, Hariri Ahmad R, Bertolino Alessandro, Mattay Venkata S, Weinberger Daniel R

Abstract excerpt

The use of polygenic risk scores has become a practical translational approach to investigating the complex genetic architecture of schizophrenia, but the link between polygenic risk scores and pathophysiological components of this disorder has been the subject of limited research. We investigated in healthy volunteers whether schizophrenia polygenic risk score predicts hippocampal activity during simple memory...

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Identifiers

PMID: 29415119
DOI: 10.1093/brain/awy004
PMCID: PMC5888989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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