Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents.

doi:10.1001/jamapsychiatry.2016.1135

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Article

Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents.

JAMA psychiatry - 1 Aug 2016

Lancaster Thomas M, Linden David E, Tansey Katherine E, Banaschewski Tobias, Bokde Arun L W, Bromberg Uli, Büchel Christian, Cattrell Anna, Conrod Patricia J, Flor Herta, Frouin Vincent, Gallinat Jürgen, Garavan Hugh, Gowland Penny, Heinz Andreas, Ittermann Bernd, Martinot Jean-Luc, Paillère Martinot Marie-Laure, Artiges Eric, Lemaitre Herve, Nees Frauke, Orfanos Dimitri Papadopoulos, Paus Tomáš, Poustka Luise, Smolka Michael N, Vetter Nora C, Jurk Sarah, Mennigen Eva, Walter Henrik, Whelan Robert, Schumann Gunter

Abstract excerpt

IMPORTANCE: Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging. OBJECTIVE: To examine whether common risk variants for psychosis are associated with individual variation in the VS. DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a large...

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PMID: 27384424
DOI: 10.1001/jamapsychiatry.2016.1135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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