Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo.

doi:10.1038/s41467-024-47456-5

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Article

Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo.

Nature communications - 30 Apr 2024

Sportelli Leonardo, Eisenberg Daniel P, Passiatore Roberta, D'Ambrosio Enrico, Antonucci Linda A, Bettina Jasmine S, Chen Qiang, Goldman Aaron L, Gregory Michael D, Griffiths Kira, Hyde Thomas M, Kleinman Joel E, Pardiñas Antonio F, Parihar Madhur, Popolizio Teresa, Rampino Antonio, Shin Joo Heon, Veronese Mattia, Ulrich William S, Zink Caroline F, Bertolino Alessandro, Howes Oliver D, Berman Karen F, Weinberger Daniel R, Pergola Giulio

Abstract excerpt

The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals. We identify...

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PMID: 38688917
DOI: 10.1038/s41467-024-47456-5
PMCID: PMC11061310

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