Article

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function

2023-09-21

Abstract excerpt

Schizophrenia (SCZ) is characterized by a polygenic risk architecture implicating diverse molecular pathways important for synaptic function. However, how polygenic risk funnels through these pathways to translate into syndromic illness is unanswered. To evaluate biologically meaningful pathways of risk, we used tensor decomposition to characterize gene co-expression in post-mortem brain (of neurotypicals: N=154;...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4b71bab-8acd-5772-8ef2-a852a35c3403
DOI: 10.1101/2023.09.20.558594

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal functionDOI 10.1101/2023.09.20.558594Read

Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo.Semantic proximity Read

DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia.Semantic proximity Read

Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk.Semantic proximity Read

Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk.Semantic proximity Read

Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network.Semantic proximity Read

A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.Semantic proximity Read

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK BiobankSemantic proximity Read

Structure–function coupling changes in first-episode, treatment-naïve schizophrenia correlate with cell type-specific transcriptional signatureSemantic proximity Read

Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric DisordersSemantic proximity Read

Schizophrenia and co-morbidity risk: Evidence from a data driven phenomewide association study.Semantic proximity Read

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosisSemantic proximity Read

Proof of concept: Molecular prediction of schizophrenia riskSemantic proximity Read