Article
Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.
Nucleic acids research - 29 Jan 2016
Westmoreland James W, Resnick Michael A
Abstract excerpt
Recombinational repair provides accurate chromosomal restitution after double-strand break (DSB) induction. While all DSB recombination repair models include 5'-3' resection, there are no studies that directly assess the resection needed for repair between sister chromatids in G-2 arrested cells of random, radiation-induced 'dirty' DSBs. Using our Pulse Field Gel Electrophoresis-shift approach, we determined...
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