Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.

Journal of molecular biology - 30 Oct 2022

Mojumdar Aditya, Mair Nicola, Adam Nancy, Cobb Jennifer A

Abstract excerpt

A double -strand break (DSB) is one of the most deleterious forms of DNA damage. In eukaryotic cells, two main repair pathways have evolved to repair DSBs, homologous recombination (HR) and non-homologous end-joining (NHEJ). HR is the predominant pathway of repair in the unicellular eukaryotic organism, S. cerevisiae. However, during replicative aging the relative use of HR and NHEJ shifts in favor of end-joining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA Breaks, Double-Stranded
Share to DNA End-Joining Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Helicases

Share to Genomics

Share to Recombinational DNA Repair

Share to RecQ Helicases

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 35998703
DOI: 10.1016/j.jmb.2022.167798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations.PMID 35998703Read ↗

Changes in DNA repair during aging.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

The ageing epigenome: damaged beyond repair?Semantic proximity Read ↗

Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.Semantic proximity Read ↗

Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrationsSemantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancerSemantic proximity Read ↗

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Semantic proximity Read ↗

The role of DNA damage and repair in aging: new approaches to an old problem.Semantic proximity Read ↗

DNA double strand break repair, aging and the chromatin connection.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

DNA Repair Defects in Stem Cell Function and AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.