Article
DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.
PLoS genetics - 1 Jan 2012
Tan Frederick J, Hoang Margaret L, Koshland Douglas
Abstract excerpt
DNA double-strand breaks impact genome stability by triggering many of the large-scale genome rearrangements associated with evolution and cancer. One of the first steps in repairing this damage is 5'→3' resection beginning at the break site. Recently, tools have become available to study the consequences of not extensively resecting double-strand breaks. Here we examine the role of Sgs1- and Exo1-dependent...
Topics
- Alleles
- Cell Cycle Checkpoints
- Chromosome Breakage
- DNA Breaks, Double-Stranded
- DNA Repair
- Diploidy
- Exodeoxyribonucleases
- Gene Rearrangement
- Genome, Fungal
- Genomic Instability
- Homologous Recombination