Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease

28 Mar 2013

Abstract excerpt

Resection is an early step in homology-directed recombinational repair (HDRR) of DNA double-strand breaks (DSBs). Resection enables strand invasion as well as reannealing following DNA synthesis across a DSB to assure efficient HDRR. While resection of only one end could result in genome instability, it has not been feasible to address events at both ends of a DSB, or to distinguish 1- versus 2-end resections at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23555316
DOI: 10.1371/journal.pgen.1003420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-NucleasePMID 23555316Read ↗

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.Semantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.Semantic proximity Read ↗

DNA end resection is needed for the repair of complex lesions in G1-phase human cellsSemantic proximity Read ↗

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.Semantic proximity Read ↗

Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.Semantic proximity Read ↗

Dna2 initiates resection at clean DNA double-strand breaks.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.