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Article

Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.

PLoS genetics - 13 May 2010

Chung Woo-Hyun, Zhu Zhu, Papusha Alma, Malkova Anna, Ira Grzegorz

Abstract excerpt

The formation of single-stranded DNA (ssDNA) at double-strand break (DSB) ends is essential in repair by homologous recombination and is mediated by DNA helicases and nucleases. Here we estimated the length of ssDNA generated during DSB repair and analyzed the consequences of elimination of processive resection pathways mediated by Sgs1 helicase and Exo1 nuclease on DSB repair fidelity. In wild-type cells during...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20485519
DOI: 10.1371/journal.pgen.1000948
PMCID: PMC2869328

Genes

PIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.PMID 20485519Read ↗

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