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Article

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

18 Aug 2014

Abstract excerpt

Repair of DNA double strand breaks (DSBs) is influenced by the chemical complexity of the lesion. Clustered lesions (complex DSBs) are generally considered more difficult to repair and responsible for early and late cellular effects after exposure to genotoxic agents. Resection is commonly used by the cells as part of the homologous recombination (HR) pathway in S- and G2-phase. In contrast, DNA resection in...

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PMID: 25486192
DOI: 10.4161/15384101.2015.941743

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