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Article

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.

Genes & development - 15 Oct 2008

Gravel Serge, Chapman J Ross, Magill Christine, Jackson Stephen P

Abstract excerpt

A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homologous recombination (HR). Here, we reveal that in the absence of exonuclease Exo1 activity, deletion or mutation of the Saccharomyces cerevisiae RecQ-family helicase, Sgs1, causes pronounced hypersensitivity to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18923075
DOI: 10.1101/gad.503108
PMCID: PMC2569880

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DNA helicases Sgs1 and BLM promote DNA double-strand break resection.PMID 18923075Read ↗

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RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read ↗

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Semantic proximity Read ↗

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