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Article

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.

Nucleic acids research - 16 Dec 2021

Bazzano Dominic, Lomonaco Stephanie, Wilson Thomas E

Abstract excerpt

Resection of the 5'-terminated strand at DNA double-strand breaks (DSBs) is the critical regulated step in the transition to homologous recombination. Recent studies have described a multi-step model of DSB resection where endonucleolytic cleavage mediated by Mre11 and Sae2 leads to further degradation mediated by redundant pathways catalyzed by Exo1 and Sgs1/Dna2. These models have not been well tested at...

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Identifiers

PMID: 34263309
DOI: 10.1093/nar/gkab597
PMCID: PMC8682756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.PMID 34263309Read ↗

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Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast.Semantic proximity Read ↗

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-NucleaseSemantic proximity Read ↗

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