Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.

doi:10.1093/nar/gkab597

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Article

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.

Nucleic acids research - 16 Dec 2021

Bazzano Dominic, Lomonaco Stephanie, Wilson Thomas E

Abstract excerpt

Resection of the 5'-terminated strand at DNA double-strand breaks (DSBs) is the critical regulated step in the transition to homologous recombination. Recent studies have described a multi-step model of DSB resection where endonucleolytic cleavage mediated by Mre11 and Sae2 leads to further degradation mediated by redundant pathways catalyzed by Exo1 and Sgs1/Dna2. These models have not been well tested at...

Topics

Alleles
Base Sequence
DNA
DNA Breaks, Double-Stranded
DNA End-Joining Repair
Exodeoxyribonucleases
Fungal Proteins
Gene Deletion
MRE11 Homologue Protein
Mitosis
RecQ Helicases
Recombinational DNA Repair
Saccharomycetales

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Identifiers

PMID: 34263309
DOI: 10.1093/nar/gkab597
PMCID: PMC8682756

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