Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.

PLoS genetics - 1 Sept 2009

Westmoreland Jim, Ma Wenjian, Yan Yan, Van Hulle Kelly, Malkova Anna, Resnick Michael A

Abstract excerpt

Resection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about processing of random "dirty-ended" DSBs created by DNA damaging agents such as ionizing radiation. Here we present a novel system for monitoring early events in the repair of random DSBs, based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Fungal
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

Share to Exodeoxyribonucleases

Share to G2 Phase

Share to Gamma Rays

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19763170
DOI: 10.1371/journal.pgen.1000656
PMCID: PMC2734177

Genes

RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.PMID 19763170Read ↗

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-NucleaseSemantic proximity Read ↗

Recombinational repair of radiation-induced double-strand breaks occurs in the absence of extensive resection.Semantic proximity Read ↗

Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.Semantic proximity Read ↗

DNA end resection is needed for the repair of complex lesions in G1-phase human cellsSemantic proximity Read ↗

Regulation of hetDNA Length during Mitotic Double-Strand Break Repair in Yeast.Semantic proximity Read ↗

RPA coordinates DNA end resection and prevents formation of DNA hairpins.Semantic proximity Read ↗

Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA resection at chromosome breaks promotes genome stability by constraining non-allelic homologous recombination.Semantic proximity Read ↗

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.Semantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.