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Article

Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1.

The Journal of endocrinology - 1 Jan 2016

Albury-Warren Toya M, Pandey Veethika, Spinel Lina P, Masternak Michal M, Altomare Deborah A

Abstract excerpt

Protein kinase B/AKT has three isoforms (AKT1-3) and is renowned for its central role in the regulation of cell growth and proliferation, due to its constitutive activation in various cancers. AKT2, which is highly expressed in insulin-responsive tissues, has been identified as a primary regulator of glucose metabolism as Akt2 knockout mice (Akt2(-/-)) are glucose-intolerant and insulin-resistant. However, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26487674
DOI: 10.1530/JOE-15-0288
PMCID: PMC4803065

Genes

AKT1
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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