Article
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Diabetes - 1 Dec 2003
Ono Hiraku, Shimano Hitoshi, Katagiri Hideki, Yahagi Naoya, Sakoda Hideyuki, Onishi Yukiko, Anai Motonobu, Ogihara Takehide, Fujishiro Midori, Viana Amelia Y I, Fukushima Yasushi, Abe Miho, Shojima Nobuhiro, Kikuchi Masatoshi, Yamada Nobuhiro, Oka Yoshitomo, Asano Tomoichiro
Abstract excerpt
Akt is critical in insulin-induced metabolism of glucose and lipids. To investigate functions induced by hepatic Akt activation, a constitutively active Akt, NH(2)-terminally myristoylation signal-attached Akt (myr-Akt), was overexpressed in the liver by injecting its adenovirus into mice. Hepatic myr-Akt overexpression resulted in a markedly hypoglycemic, hypoinsulinemic, and hypertriglyceridemic phenotype with...
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