Article
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
The Journal of biological chemistry - 19 Oct 2001
Cho H, Thorvaldsen J L, Chu Q, Feng F, Birnbaum M J
Abstract excerpt
The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important effector for phosphatidylinositol 3-kinase signaling initiated by numerous growth factors and hormones. Akt2/PKBbeta, one of three known mammalian isoforms of Akt/PKB, has been demonstrated recently to be required for at least some of the metabolic actions of insulin (Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q.,...
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