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Article

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.

Molecular and cellular biology - 1 Nov 2006

Dummler Bettina, Tschopp Oliver, Hynx Debby, Yang Zhong-Zhou, Dirnhofer Stephan, Hemmings Brian A

Abstract excerpt

To address the issues of isoform redundancy and isoform specificity of the Akt family of protein kinases in vivo, we generated mice deficient in both Akt2 and Akt3. In these mice, only the Akt1 isoform remains to perform essential Akt functions, such as glucose homeostasis, proliferation, differentiation, and early development. Surprisingly, we found that Akt2(-/-) Akt3(-/-) and even Akt1(+/-) Akt2(-/-) Akt3(-/-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16923958
DOI: 10.1128/MCB.00722-06
PMCID: PMC1636753

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Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.PMID 16923958Read ↗

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