Article
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.
Nature communications - 22 Aug 2014
Brereton Melissa F, Iberl Michaela, Shimomura Kenju, Zhang Quan, Adriaenssens Alice E, Proks Peter, Spiliotis Ioannis I, Dace William, Mattis Katia K, Ramracheya Reshma, Gribble Fiona M, Reimann Frank, Clark Anne, Rorsman Patrik, Ashcroft Frances M
Abstract excerpt
Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid diabetes and marked...
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