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Article

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.

The Journal of clinical investigation - 1 Jul 2003

Garofalo Robert S, Orena Stephen J, Rafidi Kristina, Torchia Anthony J, Stock Jeffrey L, Hildebrandt Audrey L, Coskran Timothy, Black Shawn C, Brees Dominique J, Wicks Joan R, McNeish John D, Coleman Kevin G

Abstract excerpt

The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival, and metabolism. It remains unclear, however, whether the functions of individual Akt/PKB isoforms are distinct. To investigate the function of Akt2/PKBbeta, mice lacking this isoform were generated. Both male and female Akt2/PKBbeta-null mice exhibit mild growth deficiency and an age-dependent loss of adipose tissue or...

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Identifiers

PMID: 12843127
DOI: 10.1172/JCI16885
PMCID: PMC164287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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