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Article

Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression.

Neoplasia (New York, N.Y.) - 1 Feb 2015

Albury Toya M, Pandey Veethika, Gitto Sarah B, Dominguez Lisette, Spinel Lina P, Talarchek Jacqueline, Klein-Szanto Andres J, Testa Joseph R, Altomare Deborah A

Abstract excerpt

BACKGROUND AND AIMS: Pancreatic adenocarcinoma is a deadly disease characterized by metastatic progression and resistance to conventional therapeutics. Mutation of KRAS is the most frequent early event in pancreatic tumor progression. AKT isoforms are frequently activated in pancreatic cancer, and reports have implicated hyperactivation of AKT1, as well as AKT2, in pancreatic tumor formation. The objective here...

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Source

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Identifiers

PMID: 25748236
DOI: 10.1016/j.neo.2014.12.006
PMCID: PMC4351297

Genes

KRAS
AKT1
AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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