Article
Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice.
Endocrinology - 1 Aug 2017
Sakai Gota, Inoue Ikuo, Suzuki Tokuko, Sumita Takashi, Inukai Kouichi, Katayama Shigehiro, Awata Takuya, Yamada Tetsuya, Asano Tomoichiro, Katagiri Hideki, Noda Mitsuhiko, Shimada Akira, Ono Hiraku
Abstract excerpt
Insulin suppresses glucose output from the liver via Akt activation; however, which substrate of Akt plays the major role in transducing this effect is unclear. We tested the postnatal expression of Akt-unresponsive, constitutively active mutants of three major Akt substrates widely considered to regulate glucose metabolism [i.e., FoxO1, PGC1α, and glycogen synthase kinase-3β (GSK3β)] using adenoviral gene...
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