Article
Development of a new model system to dissect isoform specific Akt signalling in adipocytes.
The Biochemical journal - 15 Jun 2015
Kajno Esi, McGraw Timothy E, Gonzalez Eva
Abstract excerpt
Protein kinase B (Akt) kinases are critical signal transducers mediating insulin action. Genetic studies revealed that Akt1 and Akt2 signalling differentially contribute to sustain lipid and glucose homoeostasis; however Akt isoform-specific effectors remain elusive due to the lack of a suitable model system to mechanistically interrogate Akt isoform-specific signalling. To overcome those technical limitations we...
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