Article
TERT promoter mutations in periocular carcinomas: implications of ultraviolet light in pathogenesis.
The British journal of ophthalmology - 1 Feb 2016
Lin Shih-Yao, Liao Shu-Lang, Hong Jin-Bon, Chu Chia-Yu, Sheen Yi-Shuan, Jhuang Jie-Yang, Tsai Jia-Huei, Liau Jau-Yu
Abstract excerpt
BACKGROUND/AIMS: Ultraviolet light-signature mutations in the telomerase reverse transcriptase (TERT) gene promoter have been identified in cutaneous melanomas, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs). Whether these mutations also occur in periocular tumours, including periocular sebaceous carcinomas (PSCs) and in situ tumours, has not been studied. METHODS: DNA extraction, PCR and...
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