Article
TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma.
Journal of the National Cancer Institute - 1 Sept 2014
Griewank Klaus G, Murali Rajmohan, Puig-Butille Joan Anton, Schilling Bastian, Livingstone Elisabeth, Potrony Miriam, Carrera Cristina, Schimming Tobias, Möller Inga, Schwamborn Marion, Sucker Antje, Hillen Uwe, Badenas Celia, Malvehy Josep, Zimmer Lisa, Scherag André, Puig Susana, Schadendorf Dirk
Abstract excerpt
BACKGROUND: Recently, TERT promoter mutations were identified at high frequencies in cutaneous melanoma tumor samples and cell lines. The mutations were found to have a UV-signature and to lead to increased TERT gene expression. We analyzed a large cohort of melanoma patients for the presence and distribution of TERT promoter mutations and their association with clinico-pathological characteristics. METHODS: 410...
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