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Article

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2014

Griewank Klaus G, Schilling Bastian, Murali Rajmohan, Bielefeld Nicola, Schwamborn Marion, Sucker Antje, Zimmer Lisa, Hillen Uwe, Schaller Jörg, Brenn Thomas, Schadendorf Dirk, Mentzel Thomas

Abstract excerpt

Activating mutations in the TERT promoter leading to increased telomerase expression were recently identified in cutaneous melanoma and subsequently in many other types of cancer. These mutations lead to increased telomerase expression, allowing cells to proliferate continuously without entering apoptosis or senescence. Atypical fibroxanthomas and pleomorphic dermal sarcomas are genetically poorly understood...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24030750
DOI: 10.1038/modpathol.2013.168

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas.PMID 24030750Read ↗

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.Semantic proximity Read ↗

TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma.Semantic proximity Read ↗

Clinicopathological and Genomic Profiles of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma Identify Overlapping Signatures with a High Mutational Burden.Semantic proximity Read ↗

TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.Semantic proximity Read ↗

UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma.Semantic proximity Read ↗

Molecular Characterization of Atypical Fibroxanthoma and Pleomorphic Dermal SarcomaSemantic proximity Read ↗

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

Mechanistic basis of atypical TERT promoter mutations.Semantic proximity Read ↗

TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.Semantic proximity Read ↗

TERT promoter mutations in atypical melanocytic lesions: A series of seven cases with adverse melanoma-specific outcome.Semantic proximity Read ↗

TERT promoter mutations in familial and sporadic melanoma.Semantic proximity Read ↗

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