Article
TERT promoter mutation is uncommon in acral lentiginous melanoma.
Journal of cutaneous pathology - 1 Jun 2014
Liau Jau-Yu, Tsai Jia-Huei, Jeng Yung-Ming, Chu Chia-Yu, Kuo Kuan-Ting, Liang Cher-Wei
Abstract excerpt
BACKGROUND: Melanoma is a heterogeneous group of diseases with distinct sets of genetic changes. Recurrent and mutually exclusive C>T or CC>TT transition mutations were identified in the promoter region of the reverse transcriptase catalytic subunit of the telomerase gene (TERT) in melanoma recently, and it was suggested that they enhanced the expression of TERT gene and played important roles in the melanoma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
