Article
TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.
PloS one - 1 Jan 2013
Griewank Klaus G, Murali Rajmohan, Schilling Bastian, Schimming Tobias, Möller Inga, Moll Iris, Schwamborn Marion, Sucker Antje, Zimmer Lisa, Schadendorf Dirk, Hillen Uwe
Abstract excerpt
Activating mutations in the TERT promoter were recently identified in up to 71% of cutaneous melanoma. Subsequent studies found TERT promoter mutations in a wide array of other major human cancers. TERT promoter mutations lead to increased expression of telomerase, which maintains telomere length and genomic stability, thereby allowing cancer cells to continuously divide, avoiding senescence or apoptosis. TERT...
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